Werkingsmechanisme

Mechanism of Action of Antipsychotics – How Do They Work?

The key role in antipsychotic efficacy is dopamine D2 receptor blockade, which all antipsychotics exhibit to differing degrees.

First- (typical) and second-generation (atypical) antipsychotics are antagonists at dopamine D2 receptors.

Compounds that act as dopamine receptor partial agonists represent a third generation of antipsychotics.

Dopamine receptor partial agonist activity differs depending on the level of the naturally occurring dopamine in the brain.

Partial agonists display functional antagonist activity at target receptors when neurotransmitter levels are high, and display functional agonist activity when neurotransmitter levels are low.

In this section

Antipsychotic Classes

So, What’s a Partial Agonist?

The Basic Antipsychotic Action

Efficacy at Different Dopamine Receptors

D3 Receptor Affinity

When Dopamine Concentrations in the PFC are Too High or Too Low, Cognitive Deficits May Arise

Werkingsmechanismeadmin2021-06-04T09:57:48+00:00

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Mechanism of Action of Antipsychotics – How Do They Work?

In this section